Deep congenic analysis identifies many strong, context-dependent QTLs, one of which, Slc35b4, regulates obesity and glucose homeostasis.

@article{Yazbek2011DeepCA,
  title={Deep congenic analysis identifies many strong, context-dependent QTLs, one of which, Slc35b4, regulates obesity and glucose homeostasis.},
  author={Soha N Yazbek and David A Buchner and Jonathan M. Geisinger and Lindsay C Burrage and Sabrina H. Spiezio and Gabriel E Zentner and Chang-Wen Hsieh and Peter C. Scacheri and Colleen M Croniger and Joseph H. Nadeau},
  journal={Genome research},
  year={2011},
  volume={21 7},
  pages={1065-73}
}
Although central to many studies of phenotypic variation and disease susceptibility, characterizing the genetic architecture of complex traits has been unexpectedly difficult. For example, most of the susceptibility genes that contribute to highly heritable conditions such as obesity and type 2 diabetes (T2D) remain to be identified despite intensive study. We took advantage of mouse models of diet-induced metabolic disease in chromosome substitution strains (CSSs) both to characterize the… CONTINUE READING