Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasome.


The 26S proteasome is a 2.5 MDa molecular machine that executes the degradation of substrates of the ubiquitin-proteasome pathway. The molecular architecture of the 26S proteasome was recently established by cryo-EM approaches. For a detailed understanding of the sequence of events from the initial binding of polyubiquitylated substrates to the… (More)
DOI: 10.1073/pnas.1403409111


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