Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease
@article{Benabid2009DeepBS, title={Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease}, author={Alim Louis Benabid and St{\'e}phan Chabard{\`e}s and John Mitrofanis and Pierre Pollak}, journal={The Lancet Neurology}, year={2009}, volume={8}, pages={67-81} }
712 Citations
Deep Brain Stimulation of the Subthalamic Nucleus Modulates Reward-Related Behavior: A Systematic Review
- Biology, PsychologyFrontiers in Human Neuroscience
- 2020
It is found that STN-DBS decreases reward seeking in the majority of experiments, and it is argued that optogenetic-assisted circuit dissection could yield important insight into the effects of the STN on motivated behavior in health and disease.
Subthalamic nucleus deep brain stimulation for Parkinson’s disease: current trends and future directions
- BiologyExpert review of medical devices
- 2020
An update on the current uses of STN-DBS as a routine therapy as well as its experimental indications in PD, the critical aspects associated with its successful implementation and recent advances in DBS technology are provided.
Mood and behavioural effects of subthalamic stimulation in Parkinson's disease
- Psychology, BiologyThe Lancet Neurology
- 2014
Effects of the temporal pattern of subthalamic deep brain stimulation on the neuronal complexity in the globus pallidus
- Biology2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
- 2017
Regular DBS caused the largest modulation in the neurons' spiking pattern and the largest increment in encoding capabilities, both of which may be relevant to the mechanisms of therapeutic DBS.
Therapeutic High-Frequency Stimulation of the Subthalamic Nucleus in Parkinson's Disease Produces Global Increases in Cerebral Blood Flow
- BiologyJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
- 2012
It is not clear whether this CBF effect has a therapeutic role, but the impact of deep brain stimulation on cerebrovascular control warrants study from neuroscience, pathophysiological, and therapeutic perspectives.
Methodological Considerations for Neuroimaging in Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson’s Disease Patients
- MedicineJournal of clinical medicine
- 2020
A number of approaches are highlighted including the use of ultra-high field (UHF) MRI to overcome limitations of standard settings and the optimization of pre-operative planning with MRI, which may require combined expertise of traditional radiologists, clinicians, and fundamental researchers.
[Deep brain stimulation - options and limits].
- MedicinePraxis
- 2011
Deep brain stimulation (DBS) is an established procedure employed for several neurological diseases with impressive therapeutic responses to some extent, yet the exact mechanism of action on a neuronal level remains uncertain.
Effect of bilateral deep brain stimulation on the subthalamic nucleus on patients with Parkinson's disease: An observational and non-blinded study
- MedicineInterdisciplinary Neurosurgery
- 2022
The latest evidence on target selection in deep brain stimulation for Parkinson’s disease
- BiologyJournal of Clinical Neuroscience
- 2014
[Analysis of antiparkinsonian drug reduction after bilateral subthalamic deep brain stimulation].
- MedicineIdeggyogyaszati szemle
- 2010
This study quantitatively analyzes the change in use of antiparkinsonian drugs one year after subthalamic deep brain stimulator (DBS) implantation in patients with idiopathic Parkinson's disease (PD).
References
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Bilateral stimulation of the subthalamic nucleus in patients with Parkinson disease: a study of efficacy and safety.
- MedicineJournal of neurosurgery
- 2002
This study demonstrates that DBS of the STN is an effective treatment for patients with advanced, medication-refractory PD, and produced robust improvements in motor performance in these severely disabled patients while they were in the medication-off state.
Acute and long-term effects of subthalamic nucleus stimulation in Parkinson's disease.
- MedicineStereotactic and functional neurosurgery
- 1994
STN stimulation in patients suffering from severe akinetic forms of PD, postulated that the excessive output from the subthalamic nucleus plays a critical role, is carried out.
Cognitive sequelae of subthalamic nucleus deep brain stimulation in Parkinson's disease: a meta-analysis
- Medicine, PsychologyThe Lancet Neurology
- 2006
Electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease.
- MedicineThe New England journal of medicine
- 1998
Electrical stimulation of the subthalamic nucleus is an effective treatment for advanced Parkinson's disease and the severity of symptoms off medication decreases, and the dose of levodopa can be reduced with consequent reduction in dyskinesias.
Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease.
- Medicine, BiologyBrain : a journal of neurology
- 2007
Findings indicate that, in patients with advanced Parkinson's disease, PPN-DBS associated with standard STN- DBS may be useful in improving gait and in optimizing the dopamine-mediated ON-state, particularly in those whose response to STN only DBS has deteriorated over time.
Deep-brain stimulation in Parkinson's disease: long-term efficacy and safety – What happened this year?
- MedicineCurrent opinion in neurology
- 2005
The stable efficacy of high-frequency stimulation of the subthalamic nucleus on Parkinson's disease motor symptoms is confirmed and the safety and inocuity of the method legitimizes earlier operations, before impairment of the quality of life.
Effects of bilateral stimulation of the subthalamic nucleus in patients with severe Parkinson's disease and motor fluctuations
- Medicine, PsychologyMovement disorders : official journal of the Movement Disorder Society
- 2002
Bilateral DBS of STN is a significant progress in treatment of advanced idiopathic Parkinson's disease with levodopa‐induced motor complications and, on medication, a significant reduction in duration of dyskinesias and duration of off‐periods.
A randomized trial of deep-brain stimulation for Parkinson's disease.
- Medicine, PsychologyThe New England journal of medicine
- 2006
In this six-month study of patients under 75 years of age with severe motor complications of Parkinson's disease, neurostimulation of the subthalamic nucleus was more effective than medical management alone.
Follow-up of bilateral subthalamic deep brain stimulation for Parkinson's disease.
- MedicineActa neurochirurgica. Supplement
- 2006
Bilateral STN-DBS is a satisfying surgical method for the treatment of advanced Parkinson's disease and can improve the cardinal PD symptoms up to 45 months.
Long-term follow up of bilateral deep brain stimulation of the subthalamic nucleus in patients with advanced Parkinson disease.
- MedicineJournal of neurosurgery
- 2003
In this group of patients with advanced PD who underwent bilateral DBS of the STN, sustained improvement in motor function was present a mean of 2 years after the procedure, and sustained reductions in drug requirements were also achieved.