Deep brain stimulation of the forniceal area enhances memory functions in experimental dementia: the role of stimulation parameters.

@article{Hescham2013DeepBS,
  title={Deep brain stimulation of the forniceal area enhances memory functions in experimental dementia: the role of stimulation parameters.},
  author={Sarah A Hescham and Lee Wei Lim and Ali Jahanshahi and Harry W. M. Steinbusch and Jos Prickaerts and Arjan Blokland and Yasin Temel},
  journal={Brain stimulation},
  year={2013},
  volume={6 1},
  pages={72-7}
}
Deep brain stimulation (DBS) is currently being evaluated as a potential therapy in improving memory functions in Alzheimer's disease. The target for DBS and the stimulation parameters to be used are unknown. Here, we implanted bilateral electrodes in the vicinity of the fornix, a key element of the memory circuitry, and applied DBS with different stimulation frequencies and amplitudes in an experimental model of dementia. Rats received scopolamine, a muscarinic acetylcholine receptor… CONTINUE READING

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