Deep brain stimulation for treatment-resistant depression: Efficacy, safety and mechanisms of action

@article{Anderson2012DeepBS,
  title={Deep brain stimulation for treatment-resistant depression: Efficacy, safety and mechanisms of action},
  author={Rodney J. Anderson and Mark A. Frye and Osama A. Abulseoud and Kendall H. Lee and Jane McGillivray and Michael Berk and Susannah J. Tye},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2012},
  volume={36},
  pages={1920-1933}
}
Deep brain stimulation (DBS), a neuromodulation therapy that has been used successfully in the treatment of symptoms associated with movement disorders, has recently undergone clinical trials for individuals suffering from treatment-resistant depression (TRD). Although the small patient numbers and open label study design limit our ability to identify optimum targets and make definitive conclusions about treatment efficacy, a review of the published research demonstrates significant reductions… Expand
Deep brain stimulation for treatment-resistant depression: a safe and effective option
TLDR
DBS for TRD might become a first-line of treatment, especially using directional leads, that may help to improve therapeutic effects, and DBS can modulate different targets, and others are under investigation. Expand
Deep brain stimulation for treatment-resistant depression: an integrative review of preclinical and clinical findings and translational implications
TLDR
An integrative review on major neuroanatomical targets of DBS pursued for the treatment of intractable TRD to determine which brain target(s) elicited the most promising outcomes considering acute and maintenance treatment of TRD. Expand
Deep Brain Stimulation for Treatment-Resistant Depression: Review of the Literature
Chronic Major depression is one of the most debilitating psychiatric disorders ; 8-13% of patients are treatment resistant. DBS has been applied to the following targets: Subcallosal cingulate gyrusExpand
Deep brain stimulation targets for treating depression
TLDR
The future outlook for DBS treatment of depression is discussed in light of the fact that antidepressant effects of DBS can be achieved using different targets. Expand
Deep Brain Stimulation for Treatment-Resistant Depression: Review of the
Chronic Major depression is one of the most debilitating psychiatric disorders ; 8-13% of patients are treatment resistant. DBS has been applied to the following targets: Subcallosal cingulate gyrusExpand
The medial forebrain bundle as a deep brain stimulation target for treatment resistant depression: A review of published data
TLDR
The medial forebrain bundle (MFB) is an essential component of a network of structural and functional pathways connecting different areas possibly involved in the pathogenesis of mood disorders and should be considered as an exciting therapeutic target for DBS therapy to achieve a sustained relief in TRD patients. Expand
Deep brain stimulation in treatment-resistant depression in mice: Comparison with the CRF1 antagonist, SSR125543
TLDR
It is demonstrated that bilateral DBS of the CC and, to a lesser extent, pharmacological blockade of the CRF(1) receptor in treatment-resistant mice can attenuate several aspects of depressive-like behaviors, suggesting further that these approaches may represent valid alternatives for the treatment of drug-resistant depressed and/or anxious patients. Expand
One ring to rule them all?--Temporospatial specificity of deep brain stimulation for treatment-resistant depression.
TLDR
It is suggested that the pre-treatment depressive state is determined by the interaction of individual traits with dysfunctional adaptive processes as responses to stress, resulting in a disease-associated, overtly dysfunctional, equilibrium. Expand
Deep brain stimulation in treatment-resistant depression in mice : Comparison with the CRF 1 antagonist , SSR 125543
a r t i c l e i n f o Deep brain stimulation (DBS) has been demonstrated to represent a targeted therapeutic alternative for treatment-resistant depression. In this study, we used the unpredictableExpand
Brain stimulation treatments in bipolar disorder: A review of the current literature
TLDR
Brain stimulation in BD is derived from its use in unipolar depression, however, there are many important differences between these two disorders and more studies with a systematic approach need to be conducted on larger samples of bipolar patients with treatment-resistant characteristics. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 225 REFERENCES
Use of deep brain stimulation in treatment-resistant depression
  • D. Malone
  • Medicine
  • Cleveland Clinic Journal of Medicine
  • 2010
TLDR
Multicenter experience with chronic deep brain stimulation of the ventral capsule/ventral striatum in 17 patients with severe treatment-resistant depression has demonstrated sustained improvements across multiple scales of depression, anxiety, and global function. Expand
Treatment resistant depression as a failure of brain homeostatic mechanisms: Implications for deep brain stimulation
TLDR
The rationale for the use of DBS for TRD is reviewed in the context of the growing neuroimaging literatures exploring the biomarkers of antidepressant response, and the neural substrates of emotional regulation in both normal and pathological states. Expand
Modulating Affect, Cognition, and Behavior – Prospects of Deep Brain Stimulation for Treatment-Resistant Psychiatric Disorders
TLDR
DBS is a unique and very promising method for the treatment of therapy–resistant psychiatric patients that allows manipulating pathological neuronal networks in a very precise way and in case of the long-term studies underway for MD, patients show a stable response. Expand
Deep Brain Stimulation for Treatment-Resistant Depression
TLDR
It is suggested that disrupting focal pathological activity in limbic-cortical circuits using electrical stimulation of the subgenual cingulate white matter can effectively reverse symptoms in otherwise treatment-resistant depression. Expand
Long-Term Effects of Nucleus Accumbens Deep Brain Stimulation in Treatment-Resistant Depression: Evidence for Sustained Efficacy
TLDR
First-time, preliminary long-term data on NAcc-DBS have demonstrated a stable antidepressant and anxiolytic effect and an amelioration of QoL in this small sample of patients suffering from treatment-resistant depression. Expand
Deep brain stimulation as a new therapeutic approach in therapy-resistant mental disorders: ethical aspects of investigational treatment
TLDR
A synopsis of the DBS approach in mental disorders and the hitherto existing criteria for research is provided and some additional requirements for ethically justifiable therapeutic research employing DBS in psychiatric patients are suggested. Expand
Potential surgical targets for deep brain stimulation in treatment-resistant depression.
TLDR
Surgical intervention for TRD in the form of DBS is emerging as a viable treatment alternative to existing modalities and various surgical targets, such as the subgenual cingulate cortex, inferior thalamic peduncle, and nucleus accumbens, have been shown to be safe and to lead to beneficial effects with various stimulation parameters. Expand
Deep brain stimulation for treatment-resistant depression: follow-up after 3 to 6 years.
TLDR
Deep brain stimulation remains a safe and effective treatment for treatment-resistant depression and functional impairment in the areas of physical health and social functioning progressively improved up to the last follow-up visit. Expand
Nucleus Accumbens Deep Brain Stimulation Decreases Ratings of Depression and Anxiety in Treatment-Resistant Depression
BACKGROUND While most patients with depression respond to combinations of pharmacotherapy, psychotherapy, and electroconvulsive therapy (ECT), there are patients requiring other treatments. DeepExpand
Deep Brain Stimulation to Reward Circuitry Alleviates Anhedonia in Refractory Major Depression
TLDR
Preliminary findings suggest that DBS to the nucleus accumbens might be a hypothesis-guided approach for refractory major depression. Expand
...
1
2
3
4
5
...