Deep brain stimulation for obsessive–compulsive disorders: long-term analysis of quality of life

@article{Ooms2013DeepBS,
  title={Deep brain stimulation for obsessive–compulsive disorders: long-term analysis of quality of life},
  author={Pieter Ooms and Mariska Mantione and Martijn Figee and P. R. Schuurman and Pepijn van den Munckhof and Damiaan Denys},
  journal={Journal of Neurology, Neurosurgery \& Psychiatry},
  year={2013},
  volume={85},
  pages={153 - 158}
}
Objective To evaluate the long-term effects of deep brain stimulation (DBS) on quality of life (QOL) in therapy-refractory obsessive–compulsive disorder (OCD) patients. Design 16 patients who met Diagnostic and Statistical Manual of Mental Disorders (4th ed) (DSM-IV) criteria for OCD and were considered therapy-refractory were treated with DBS. Patients were assessed 1 month before device implantation (T0), at 8 months of active stimulation (T1) and at 3–5 years of active stimulation (T2). QOL… Expand
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Rebound of Affective Symptoms Following Acute Cessation of Deep Brain Stimulation in Obsessive-compulsive Disorder
TLDR
Acute DBS cessation causes a relapse of obsessions and compulsions and a rebound of anxiety and depression, and improvements on QoL disappear. Expand
Deep Brain Stimulation for Obsessive-Compulsive Disorder: A Meta-Analysis of Treatment Outcome and Predictors of Response
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It is confirmed that DBS constitutes a valid alternative to lesional surgery for severe, therapy-refractory OCD patients and well-controlled, randomized studies with larger samples are needed to establish the optimal targeting and stimulation conditions. Expand
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DBS of the VC/VS region did not reveal a sustained response for comorbid depressive symptoms in patients with a primary diagnosis of OCD, and DBS was safe and conferred a long-term benefit in reduction of obsessive-compulsive symptoms. Expand
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A review of DBS in obsessive-compulsive disorder, considered as a last treatment resort by most of learned societies in psychiatry, and the latest hypotheses about the understanding of cortico-striato-thalamo-cortical circuits could offer new directions including clinical predictors and biomarkers to perform adaptive closed-loop systems in the next future. Expand
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TLDR
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TLDR
Research can contribute to defining the place of DBS within treatment algorithms for OCD and will open a new perspective for OCD patients by moving the limits of refractoriness further away. Expand
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TLDR
The results showed that DBS is a cost-effective treatment for TROCD in both the countries and provides economic evidence on the applicability of DBS for patients, health care service providers, and payers. Expand
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TLDR
The critical analysis of the evidence shows that the use of DBS in treatment-resistant OCD is providing satisfactory results regarding efficacy, with assumable side-effects, however, there is insufficient evidence to support theUse of any single brain target over another. Expand
Clinical Outcome and Mechanisms of Deep Brain Stimulation for Obsessive-Compulsive Disorder
TLDR
Evidence from DBS animal models converges with human DBS EEG and imaging findings, in that DBS may be effective for OCD by reduction of hyperconnectivity between frontal and striatal areas. Expand
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