Deep brain stimulation for chronic pain investigated with magnetoencephalography

  title={Deep brain stimulation for chronic pain investigated with magnetoencephalography},
  author={Morten L. Kringelbach and Ned Jenkinson and Alexander L. Green and Sarah L. F. Owen and Peter C. Hansen and Piers L. Cornelissen and Ian E. Holliday and John F. Stein and Tipu Z. Aziz},
Deep brain stimulation has shown remarkable potential in alleviating otherwise treatment-resistant chronic pain, but little is currently known about the underlying neural mechanisms. Here for the first time, we used noninvasive neuroimaging by magnetoencephalography to map changes in neural activity induced by deep brain stimulation in a patient with severe phantom limb pain. When the stimulator was turned off, the patient reported significant increases in subjective pain. Corresponding… 
Deep brain stimulation for chronic pain
Deep brain stimulation for pain.
Translational principles of deep brain stimulation
An up-to-date overview of the principles of DBS, its neural mechanisms and its potential future applications is given.
The continued relevance of Deep Brain Stimulation for chronic pain
This work advocates use of DBS for pain, for patients for whom pharmacology has failed and for whom spinal cord stimulation is inadequate, and argues for the untapped potential for this procedure.
Deep brain stimulation of the dorsal anterior cingulate cortex for the treatment of chronic neuropathic pain.
The available neurophysiological and empirical clinical evidence suggests that dACC DBS is a viable therapeutic option for the treatment of chronic neuropathic pain and warrants further investigation.
MEG Can Map Short and Long-Term Changes in Brain Activity following Deep Brain Stimulation for Chronic Pain
An analysis of magnetoencephalography data from a patient with whole-body chronic pain finds significant changes in activity in pain-related regions including the pre-supplementary motor area, brainstem, and dissociable parts of caudal and rostral ACC.
Magnetoencephalography Characterization of Pain Anticipation in Patients with Post-Stroke Thalamic Pain
DBS of the ventral capsule was employed to modulate the affective component of pain and thereby reduce pain related disability in PSTP and departure from conventional approach.
Neuropathic Pain and Deep Brain Stimulation
Deep brain stimulation of the ventral posterior thalamus, periventricular/periaqueductal gray matter, and latterly rostral anterior cingulate cortex (Cg24) in 113 patients treated at 2 centers over 13 years is summarized.
Using magnetoencephalography to investigate brain activity during high frequency deep brain stimulation in a cluster headache patient
The results show that MEG can be used to measure brain activity regardless of the presence of high frequency deep brain stimulation.
Deep brain stimulation for cluster headache


Deep brain stimulation for the alleviation of post-stroke neuropathic pain
Deep Brain Stimulation for Neuropathic Cephalalgia
DBS can be an effective treatment for various types of intractable head and facial pains and statistically significant improvement in pain scores as well as health-related quality of life following surgery is shown.
Activation of the anterior cingulate cortex by thalamic stimulation in patients with chronic pain: a positron emission tomography study.
It is demonstrated that the ACC is activated during thalamic DBS in patients with chronic pain, and implications specific to the analgesic effect of DBS require further study of a larger, more homogeneous patient population.
Hypothalamic Deep Brain Stimulation in Positron Emission Tomography
A hitherto unrecognized functional modulation of the pain processing network as the mode of action of hypothalamic deep brain stimulation in cluster headache is suggested.
Deep brain stimulation for phantom limb pain
Brain stimulation.
  • R. Young
  • Medicine, Biology
    Neurosurgery clinics of North America
  • 1990
Deep brain stimulation for intractable pain: a 15-year experience.
DBS in selected patients provides long-term effective pain control with few side effects or complications, and patients with failed back syndrome, trigeminal neuropathy, and peripheral neuropathy fared well with DBS, whereas those with thalamic pain, spinal cord injury, and postherpetic neuralgia did poorly.
Deep brain stimulation for pain relief: A meta-analysis
Deep brain stimulation for movement disorders and pain
Deep brain stimulation for generalised dystonia and spasmodic torticollis