Deep brain stimulation creates an informational lesion of the stimulated nucleus.

@article{Grill2004DeepBS,
  title={Deep brain stimulation creates an informational lesion of the stimulated nucleus.},
  author={Warren M. Grill and Andrea N Snyder and Svjetlana Miocinovic},
  journal={Neuroreport},
  year={2004},
  volume={15 7},
  pages={1137-40}
}
Deep brain stimulation (DBS) is an effective treatment for movement disorders, but the mechanisms are unclear. DBS generates inhibition of neurons surrounding the electrode while simultaneously activating the output axons of local neurons. This dual effect does not explain two hallmarks of DBS effectiveness: symptom relief is dependent on using a sufficiently high-stimulation frequency, and clinical effects are analogous to those produced by lesion. The effect of DBS at different frequencies on… CONTINUE READING
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