Deep Sequencing of Protease Inhibitor Resistant HIV Patient Isolates Reveals Patterns of Correlated Mutations in Gag and Protease

Abstract

While the role of drug resistance mutations in HIV protease has been studied comprehensively, mutations in its substrate, Gag, have not been extensively cataloged. Using deep sequencing, we analyzed a unique collection of longitudinal viral samples from 93 patients who have been treated with therapies containing protease inhibitors (PIs). Due to the high… (More)
DOI: 10.1371/journal.pcbi.1004249

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@inproceedings{Flynn2015DeepSO, title={Deep Sequencing of Protease Inhibitor Resistant HIV Patient Isolates Reveals Patterns of Correlated Mutations in Gag and Protease}, author={William F. Flynn and Max W. Chang and Zhiqiang Tan and Glenn Oliveira and Jinyun Yuan and Jason F. Okulicz and Bruce E. Torbett and Ronald M. Levy}, booktitle={PLoS Computational Biology}, year={2015} }