Deep Sequencing Analysis of HBV Genotype Shift and Correlation with Antiviral Efficiency during Adefovir Dipivoxil Therapy

  title={Deep Sequencing Analysis of HBV Genotype Shift and Correlation with Antiviral Efficiency during Adefovir Dipivoxil Therapy},
  author={Yuwei Wang and X. Shan and Zhi-yuan Liang and Youlan Shan and W. Huang and Da-zhi Zhang and Aizhong Zen and X. Zhou and Yao Zhao and Xuyang Gong and Ge Xu and Xiuyu Zhang and Juan Chen and A. Huang},
  journal={PLoS ONE},
Background Viral genotype shift in chronic hepatitis B (CHB) patients during antiviral therapy has been reported, but the underlying mechanism remains elusive. Methods 38 CHB patients treated with ADV for one year were selected for studying genotype shift by both deep sequencing and Sanger sequencing method. Results Sanger sequencing method found that 7.9% patients showed mixed genotype before ADV therapy. In contrast, all 38 patients showed mixed genotype before ADV treatment by deep… Expand
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