Deep-Sequence Identification and Role in Virus Replication of a JC Virus Quasispecies in Patients with Progressive Multifocal Leukoencephalopathy.

Abstract

JC virus (JCV) is a DNA virus causing progressive multifocal leukoencephalopathy (PML) in immunodeficient patients. In the present study, 22 genetic quasispecies with more than 1.5% variant frequency were detected in JCV genomes from six clinical samples of PML by next-generation sequencing. A mutation from A to C at nucleotide (nt) 3495 in JCV Mad1… (More)

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Cite this paper

@article{Takahashi2017DeepSequenceIA, title={Deep-Sequence Identification and Role in Virus Replication of a JC Virus Quasispecies in Patients with Progressive Multifocal Leukoencephalopathy.}, author={Kenta Takahashi and Tsuyoshi Sekizuka and Hitomi Fukumoto and Kazuo Nakamichi and Tadaki Suzuki and Yuko Sato and Hideki Hasegawa and Makoto Kuroda and Harutaka Katano}, journal={Journal of virology}, year={2017}, volume={91 1} }