Deep Resequencing Unveils Genetic Architecture of ADIPOQ and Identifies a Novel Low-Frequency Variant Strongly Associated With Adiponectin Variation

@inproceedings{Warren2012DeepRU,
  title={Deep Resequencing Unveils Genetic Architecture of ADIPOQ and Identifies a Novel Low-Frequency Variant Strongly Associated With Adiponectin Variation},
  author={Liling L. Warren and Li Li and Matthew R. Nelson and Margaret G. Ehm and Judong Shen and Dana Fraser and Jennifer L. Aponte and Keith L. Nangle and Andrew J. Slater and Peter M Woollard and Matt D. Hall and Simon D Topp and Xin Yuan and Lon R. Cardon and Stephanie L. Chissoe and Vincent E. Mooser and Andrew D. Morris and Colin N A Palmer and John R B Perry and Timothy M. Frayling and John C. Whittaker and Dawn Waterworth},
  booktitle={Diabetes},
  year={2012}
}
Increased adiponectin levels have been shown to be associated with a lower risk of type 2 diabetes. To understand the relations between genetic variation at the adiponectin-encoding gene, ADIPOQ, and adiponectin levels, and subsequently its role in disease, we conducted a deep resequencing experiment of ADIPOQ in 14,002 subjects, including 12,514 Europeans, 594 African Americans, and 567 Indian Asians. We identified 296 single nucleotide polymorphisms (SNPs), including 30 amino acid changes… CONTINUE READING
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