Deep Brain Stimulation to Reward Circuitry Alleviates Anhedonia in Refractory Major Depression

@article{Schlaepfer2008DeepBS,
  title={Deep Brain Stimulation to Reward Circuitry Alleviates Anhedonia in Refractory Major Depression},
  author={Thomas E. Schlaepfer and Michael X. Cohen and Caroline Frick and Markus Kosel and Daniela Brodesser and Nikolai Axmacher and Alexius Young Joe and M. Kreft and Doris Lenartz and Volker Sturm},
  journal={Neuropsychopharmacology},
  year={2008},
  volume={33},
  pages={368-377}
}
Deep brain stimulation (DBS) to different sites allows interfering with dysfunctional network function implicated in major depression. Because a prominent clinical feature of depression is anhedonia—the inability to experience pleasure from previously pleasurable activities—and because there is clear evidence of dysfunctions of the reward system in depression, DBS to the nucleus accumbens might offer a new possibility to target depressive symptomatology in otherwise treatment-resistant… 

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