Deep Brain Stimulation of the Human Reward System for Major Depression—Rationale, Outcomes and Outlook

@article{Schlaepfer2014DeepBS,
  title={Deep Brain Stimulation of the Human Reward System for Major Depression—Rationale, Outcomes and Outlook},
  author={Thomas E. Schlaepfer and Bettina H. Bewernick and Sarah Kayser and Ren{\'e} Hurlemann and Volker Arnd Coenen},
  journal={Neuropsychopharmacology},
  year={2014},
  volume={39},
  pages={1303-1314}
}
Deep brain stimulation (DBS) as a putative approach for treatment-resistant depression (TRD) has now been researched for about a decade. Several uncontrolled studies—all in relatively small patient populations and different target regions—have shown clinically relevant antidepressant effects in about half of the patients and very recently, DBS to a key structure of the reward system, the medial forebrain bundle, has yielded promising results within few days of stimulation and at much lower… CONTINUE READING
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