Deep Brain Stimulation for Tourette-Syndrome: A Systematic Review and Meta-Analysis

@article{Baldermann2016DeepBS,
  title={Deep Brain Stimulation for Tourette-Syndrome: A Systematic Review and Meta-Analysis},
  author={Juan Carlos Baldermann and Thomas Sch{\"u}ller and Daniel Huys and Ingrid Becker and Lars Timmermann and Frank Jessen and Veerle Visser-Vandewalle and Jens Kuhn},
  journal={Brain Stimulation},
  year={2016},
  volume={9},
  pages={296-304}
}
Deep Brain Stimulation Results in Greater Symptomatic Improvement in Tourette Syndrome than Conservative Measures: A Meta-Analysis
TLDR
It is suggested that adult patients with refractory TS undergoing DBS experience greater symptomatic improvement with surprisingly low morbidity than can be obtained with pharmacotherapy or psychotherapy.
Deep Brain Stimulation for Tourette Syndrome.
TLDR
The registry results mirror those described in a systematic review and meta-analysis of DBS for TS that was published in 2016 and should encourage movement disorder groups to consider treating refractory TS with DBS.
Target-Specific Effects of Deep Brain Stimulation for Tourette Syndrome: A Systematic Review and Meta-Analysis
TLDR
It is concluded that DBS is a clinically effective treatment option for patients with treatment-refractory Tourette syndrome, with all targets showing comparable improvement rates.
Deep Brain Stimulation for Refractory Tourette Syndrome: Electrode Position and Clinical Outcome
TLDR
DBS is an effective treatment for refractory TS, although careful indication is necessary because of the surgical risks and unknown long-term outcome, and effectiveness and stimulation conditions were equivalent to international reports.
Neuroanatomical Considerations for Optimizing Thalamic Deep Brain Stimulation in Tourette Syndrome
TLDR
This study addresses the importance of accurate implantation of DBS electrodes for obtaining standardised clinical outcomes and suggests that meticulous programming with careful monitoring of clinical symptoms may improve outcomes.
Deep Brain Stimulation for Tourette Syndrome: Potential Role in the Pediatric Population
TLDR
Analysis of published reports on the use of deep brain stimulation in Tourette syndrome reveals that 2 anatomical targets have been most commonly used: the centromedian thalamus and the globus pallidus internus.
Deep brain stimulation for Gilles de la Tourette syndrome in children and youth: a meta-analysis with individual participant data.
TLDR
DBS in the pediatric population may be an effective option with a moderate safety profile for treatment of GTS in carefully selected children and youth using individual participant data (IPD) meta-analysis methodology.
Deep brain stimulation in Tourette syndrome: the known and the unknown.
TLDR
The paper by Johnson et al 1 is based on a collaboration with the International Tourette Syndrome (TS) Deep Brain Stimulation (DBS) database and registry and aims to collect as many data as possible to increase the database on efficacy, safety and surgical approaches of DBS in TS.
Deep Brain Stimulation for Gilles de la Tourette Syndrome: Toward Limbic Targets
TLDR
It is confirmed that DBS is an effective therapy in treating GTS and suggested that the am-GPi might be superior to Voi-Cm/Pf in alleviating comorbid OCD/OCB.
Deep brain stimulation in Tourette syndrome: the known and the unknown
  • K. Muller-Vahl
  • Medicine
    Journal of Neurology, Neurosurgery, and Psychiatry
  • 2019
TLDR
This is the first study that aimed to identify the optimal target for DBS in patients with TS including a large sample of N=110 patients from 13 different institutions across three different continents by using the DBS TS database/registry and a meta-analysis.
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References

SHOWING 1-10 OF 86 REFERENCES
Lessons Learned from Open-label Deep Brain Stimulation for Tourette Syndrome: Eight Cases over 7 Years
TLDR
The open-label experience with eight patients with severe refractory malignant TS treated with DBS supports the urgent need for more data and refinements in interventions and outcome measurements for severe, malignant, and medication-refracted TS.
Unfavourable outcome of deep brain stimulation in a Tourette patient with severe comorbidity
TLDR
The nature of the complications, the implications for patient selection, and the outcome of DBS in an institutionalized patient with intractable Tourette syndrome and severe comorbidity are discussed.
Deep brain stimulation in Tourette's syndrome: Two targets?
TLDR
Data show that bilateral DBS of the thalamus as well as of the GPi can have a good effect on tics and behavioral symptoms in patients suffering from intractable Tourette’s syndrome.
Deep brain stimulation for treatment of refractory Tourette syndrome: long-term follow-up
TLDR
DBS was very successful in terms of a significant improvement in tics and also a significant reduction in the potentially disabling symptoms of obsessionality, anxiety and depression, however, compared with the more positive overall results at 2 years, these later results demonstrate long-term difficulties.
A trial of scheduled deep brain stimulation for Tourette syndrome: moving away from continuous deep brain stimulation paradigms.
TLDR
This study provides safety and proof of concept that a scheduled DBS approach could improve motor and vocal tics in Tourette syndrome and holds promise as a potential first step for shifting movement and neuropsychiatric disorders toward more responsive neuromodulation approaches.
Tourette syndrome deep brain stimulation: A review and updated recommendations
  • L. Schrock, J. Mink, M. Okun
  • Medicine
    Movement disorders : official journal of the Movement Disorder Society
  • 2015
TLDR
Tourette syndrome DBS, though still evolving, is a promising approach for a subset of medication refractory and severely affected patients and should be offered to patients only by experienced DBS centers after evaluation by a multidisciplinary team.
Deep brain stimulation in 18 patients with severe Gilles de la Tourette syndrome refractory to treatment: the surgery and stimulation
TLDR
The results of this and previous DBS reports suggest that the CM–Pfc and ventralis oralis complex of the thalamus may be a good DBS target for GTS.
Double-blind clinical trial of thalamic stimulation in patients with Tourette syndrome.
Deep brain stimulation of the thalamus has been proposed as a therapeutic option in patients with Tourette syndrome who are refractory to pharmacological and psychotherapeutic treatment. Patients
Deep Brain Stimulation of the Antero-Medial Globus Pallidus Interna for Tourette Syndrome
TLDR
This case series provides further support that antero-medial GPi DBS is an effective and well tolerated treatment for a subgroup of severe TS, with benefits sustained up to 4 years.
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