Deep Brain Stimulation
@article{Chen2013DeepBS, title={Deep Brain Stimulation}, author={X.L. Chen and Yunyun Xiong and G. L. Xu and X.-F. Liu}, journal={Interventional Neurology}, year={2013}, volume={1}, pages={200 - 212} }
Deep brain stimulation (DBS) has provided remarkable therapeutic benefits for people with a variety of neurological disorders. Despite the uncertainty of the precise mechanisms underlying its efficacy, DBS is clinically effective in improving motor function of essential tremor, Parkinson's disease and primary dystonia and in relieving obsessive-compulsive disorder. Recently, this surgical technique has continued to expand to other numerous neurological diseases with encouraging results. This…
1,030 Citations
Mechanism of Deep Brain Stimulation
- MedicineThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
- 2016
This short review would like to introduce the recent work on the physiological mechanism of DBS and propose an alternative explanation: DBS dissociates input and output signals, resulting in the disruption of abnormal information flow through the stimulation site.
Deep brain stimulation and multiple sclerosis: Therapeutic applications.
- Medicine, PsychologyMultiple sclerosis and related disorders
- 2014
The Role of Deep Brain Stimulation Procedure on the Quality of Life in Patients with Parkinson’s Disease
- Medicine, PsychologyCroatian Nursing Journal
- 2018
The goal of DBS is improving the quality of life of patients, specifically by improving their motor function, reduction in drug therapy they use as well as reducing pain and neurological deficits.
Deep Brain Stimulation- A Novel Approach For Relieving Neurological Disorders: A Review
- MedicineInternational Journal of Contemporary Medicine, Surgery and Radiology
- 2018
The principle mechanism of action of deep brain stimulation (DBS) advantages, limitations and it’s amazing application in the management of various neurological disorders are highlighted.
Deep Brain Stimulation: Technology at the Cutting Edge
- Medicine, PsychologyJournal of clinical neurology
- 2010
Current and emerging evidence for the role of DBS in the management of a range of neurological and psychiatric conditions are reviewed, and the technical and practical aspects of performing DBS surgery are discussed.
A brief review of deep brain stimulation for treatment of neurological diseases
- Medicine2015 International Conference and Workshop on Computing and Communication (IEMCON)
- 2015
The Implantable Pulse Generator (IPG) of the brain pacemaker system has been a magnificent treatment to reactivate the almost dead cells pros and cons of the deep brain stimulation mechanism and the platform to make it more compact and smarter in the future.
Disrupting neuronal transmission: mechanism of DBS?
- MedicineFront. Syst. Neurosci.
- 2014
This review will examine the neurophysiological mechanism underling the action of DBS and propose the alternative interpretation: DBS dissociates inputs and outputs, resulting in disruption of abnormal signal transmission.
Deep Brain Stimulation (DBS) : Current and Emerging Applications
- Medicine, Psychology
- 2014
This manuscript provides a review of the current application of DBS surgery in movement disorders, psychiatric and other conditions and an overview of the recent advances in the understanding of the neural circuitry underpinning the pathophysiology of these disorders.
Pallidal deep brain stimulation modulates cortical excitability and plasticity
- Medicine, BiologyAnnals of neurology
- 2018
The modulation of motor cortical excitability and plasticity with single‐pulse GPi DBS in dystonia patients with bilateral implantation of GPI DBS is studied.
Deep Brain Stimulation Improves Brain Efficiency in Essential Tremor Patients
- Medicine
- 2017
The movement disorder essential tremor can be treated with deep brain stimulation (DBS), where electric current is delivered to deep brain structures through permanently implanted electrodes. In th…
493 References
Translational principles of deep brain stimulation
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An up-to-date overview of the principles of DBS, its neural mechanisms and its potential future applications is given.
Deep brain stimulation: What can patients expect from it?
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Deep brain stimulation has largely replaced ablative procedures for the treatment of advanced Parkinson disease, essential tremor, and dystonia. It is also approved for obsessive-compulsive disorder.…
Deep brain stimulation: current and future clinical applications.
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This review summarizes many of the current and potential future clinical applications of deep brain stimulation and indicates that a decrease in medication can be instrumental in reducing the disabling features of dyskinesias in patients with Parkinson disease.
Deep brain stimulation and the role of astrocytes
- Medicine, BiologyMolecular Psychiatry
- 2012
The potential role of reactive and neurogenic astrocytes (neural progenitors) in DBS will be discussed, and how high-frequency stimulation of these cells may lead to alleviation of the clinical symptoms is discussed.
Deep brain stimulation in neurological diseases and experimental models: From molecule to complex behavior
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The evolution of deep brain stimulation for neuropsychiatric disorders.
- Psychology, MedicineFrontiers in bioscience : a journal and virtual library
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Deep brain stimulation (DBS) is the most focal method for stimulating the human brain, with the advantages of reversibility and adjustability, and while DBS is an approved adjunct therapy for severe, medication-refractory movement disorders, it remains investigational in neuropsychiatry.
Deep brain stimulation state of the art and novel stimulation targets.
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Deep Brain Stimulation of the Subthalamic Nucleus for Peripherally Induced Parkinsonism
- Medicine, PsychologyNeuromodulation : journal of the International Neuromodulation Society
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Most patients with peripherally-induced parkinsonism develop symptoms that extend beyond the original site of injury, suggesting involvement of the central nervous system, possibly through reorganization in response to altered peripheral input.
Uncovering the mechanisms of deep brain stimulation for Parkinson's disease through functional imaging, neural recording, and neural modeling.
- Biology, MedicineCritical reviews in biomedical engineering
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This review addresses the main hypotheses on the mechanisms of action of DBS and concludes that stimulation-induced desynchronization of network oscillations represents the hypothesis that best explains the presently available data.
Central Thalamic Deep Brain Stimulation to Promote Recovery from Chronic Posttraumatic Minimally Conscious State: Challenges and Opportunities
- Psychology, BiologyNeuromodulation : journal of the International Neuromodulation Society
- 2012
The methodology used in the CT‐DBS protocol developed by the group is reviewed, the challenges the group encountered are outlined and suggestions for future DBS trials in this population are offered.