Deducing the stage of origin of Wilms' tumours from a developmental series of Wt1-mutant mice

@inproceedings{Berry2015DeducingTS,
  title={Deducing the stage of origin of Wilms' tumours from a developmental series of Wt1-mutant mice},
  author={Rachel L. Berry and Derya Deniz Ozdemir and Bruce J. Aronow and Nils Olof Lindstr{\"o}m and Tatiana Dudnakova and Anna Thornburn and Paul Perry and Richard Baldock and Chris Armit and Anagha Joshi and C{\'e}cile Jeanpierre and Jingdong Shan and Seppo J Vainio and James E Baily and David G. Brownstein and Jamie Davies and Nicholas D Hastie and Peter Hohenstein},
  booktitle={Disease models & mechanisms},
  year={2015}
}
Wilms' tumours, paediatric kidney cancers, are the archetypal example of tumours caused through the disruption of normal development. The genetically best-defined subgroup of Wilms' tumours is the group caused by biallelic loss of the WT1 tumour suppressor gene. Here, we describe a developmental series of mouse models with conditional loss of Wt1 in… CONTINUE READING
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