Dedifferentiation precedes invasion in the progression from Barrett's metaplasia to esophageal adenocarcinoma.

@article{Helm2005DedifferentiationPI,
  title={Dedifferentiation precedes invasion in the progression from Barrett's metaplasia to esophageal adenocarcinoma.},
  author={James F. Helm and Steven A. Enkemann and Domenico Coppola and James S. Barthel and Scott T. Kelley and Timothy J. Yeatman},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2005},
  volume={11 7},
  pages={
          2478-85
        }
}
PURPOSE Adenocarcinoma arises in Barrett's esophagus by progression from metaplasia to cancer through grades of dysplasia. Our aim in this exploratory study was to characterize the broad changes in gene expression that underlie this histologic progression to cancer and assess the potential for using these gene expression changes as a marker predictive of malignant progression in Barrett's epithelium. EXPERIMENTAL DESIGN Microarray analysis was used to obtain individual gene expression… CONTINUE READING

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