Dedifferentiation of stromal smooth muscle as a factor in prostate carcinogenesis.

@article{Wong2002DedifferentiationOS,
  title={Dedifferentiation of stromal smooth muscle as a factor in prostate carcinogenesis.},
  author={Y H Colin Wong and Neville Ngai-Chung Tam},
  journal={Differentiation; research in biological diversity},
  year={2002},
  volume={70 9-10},
  pages={633-45}
}
We had earlier established an animal model of prostate carcinogenesis using a combination of testosterone (T) and 17beta-estradiol benzoate (E2) on Noble rats (Wang and Wong, 1998). In the present study we examined the changes in a number of smooth muscle differentiation markers including smooth muscle alpha-actin and myosin, vinculin, desmin, laminin and vimentin as well as changes in fine structure by electron microscopy. Our immunohistochemical (IHC) studies revealed that smooth muscle cells… CONTINUE READING

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