Dedifferentiation of conditionally immortalized hepatocytes with long-term in vitro passage

@article{Kim2000DedifferentiationOC,
  title={Dedifferentiation of conditionally immortalized hepatocytes with long-term in vitro passage},
  author={B H Kim and Se-Ra Sung and E Choi and Y Kim and Kyeong-Jin Kim and Seok-Ho Dong and Hyo-Jong Kim and Young Woon Chang and Joung-Il Lee and Rin Chang},
  journal={Experimental & Molecular Medicine},
  year={2000},
  volume={32},
  pages={29-37}
}
The rat hepatocytes were immortalized using a temperature-sensitive mutant of SV40 large T antigen (tsT) to develop as a possible substitute for primary hepatocytes. Four rat hepatocyte lines that have been developed and maintained more than passage 50, were characterized for their cellular morphology, T antigen and p53 expression, chromosomes, liver-specific differentiation, telomerase activity and anchorage independent growth. All of four cell lines showed a typical epithelial cell morphology… CONTINUE READING
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Prompt activation of telomerase by chemical carcinogens in rats detected with a modified TRAP assay

  • M. Miura, Y. Karasaki, A. Tetsuya, K. Higashi, K. Ikemura, S. Gotoh
  • Virology
  • 1998
1 Excerpt

The regulation of p53 function: Steiner Award Lecture

  • D. P. Lane
  • Int . J . Cancer
  • 1994
2 Excerpts

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