Dedifferentiation of Glioma Cells to Glioma Stem-like Cells By Therapeutic Stress-induced HIF Signaling in the Recurrent GBM Model.

@article{Lee2016DedifferentiationOG,
  title={Dedifferentiation of Glioma Cells to Glioma Stem-like Cells By Therapeutic Stress-induced HIF Signaling in the Recurrent GBM Model.},
  author={Gina Shu Hui. Lee and Brenda M. Auffinger and Donna Guo and Tanwir Hasan and Marc Deheeger and Alex L. Tobias and Jeong Yeon Kim and Fatemeh Atashi and Lingjiao Zhang and Maciej S. Lesniak and C. David James and Atique U Ahmed},
  journal={Molecular cancer therapeutics},
  year={2016},
  volume={15 12},
  pages={
          3064-3076
        }
}
Increasing evidence exposes a subpopulation of cancer cells, known as cancer stem cells (CSCs), to be critical for the progression of several human malignancies, including glioblastoma multiforme. CSCs are highly tumorigenic, capable of self-renewal, and resistant to conventional therapies, and thus considered to be one of the key contributors to disease recurrence. To elucidate the poorly understood evolutionary path of tumor recurrence and the role of CSCs in this process, we developed… CONTINUE READING
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Stem Cell Genetics for Biomedical Research

  • Springer International Publishing
  • 2018
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