Decytabine enhances cytotoxicity induced by oxaliplatin and 5-fluorouracil in the colorectal cancer cell line Colo-205

@article{Flis2009DecytabineEC,
  title={Decytabine enhances cytotoxicity induced by oxaliplatin and 5-fluorouracil in the colorectal cancer cell line Colo-205},
  author={Sylwia Flis and Agnieszka Gnyszka and Irena Misiewicz-Krzemińska and Jacek Spławiński},
  journal={Cancer Cell International},
  year={2009},
  volume={9},
  pages={10 - 10}
}
DNA methylation is an epigenetic phenomenon known to play an important role in the development of cancers, including colorectal cancer (CRC). Aberrant methylation of promoter regions of genes is potentially reversible, and if methylation is important for cancer survival, demethylation should do the opposite. To test this we have addressed the hypothesis that DNA methyltransferase inhibitors (DNMTi), decytabine and zebularine, potentiate inhibitory effects of classical anti-CRC cytostatics… CONTINUE READING

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