Dection of strand breaks in φX 174 RFI and PM2 DNA reacted with ultimate and proximate carcinogens

@article{Thielmann1977DectionOS,
  title={Dection of strand breaks in φX 174 RFI and PM2 DNA reacted with ultimate and proximate carcinogens},
  author={Heinz Walter Thielmann},
  journal={Zeitschrift f{\"u}r Krebsforschung und Klinische Onkologie},
  year={1977},
  volume={90},
  pages={37-69}
}
Supercoiled DNA duplexes of phages φX 174 and PM2 were treated in aqueous solution at neutral pH with ultimate and proximate carcinogens. Subsequently, the carcinogen-treated phage DNAs were subjected to velocity sedimentation in neutral and alkaline sucrose to quantitate introduction of single strand breaks. Reaction of phage DNA with the ultimate carcinogens N-methyl-N-nitrosourea (MeNOUr), N-ethyl-N-nitrosourea (EtNOUr), 7-bromomethyl-benz[a]-anthracene, N-acetoxy-2-acetylaminofluorene [(Ac… CONTINUE READING
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