Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells.

@article{Barrett2009Dectin2RO,
  title={Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells.},
  author={Nora A Barrett and Akiko Maekawa and Opu M. Rahman and K Frank Austen and Yoshihide Kanaoka},
  journal={Journal of immunology},
  year={2009},
  volume={182 2},
  pages={1119-28}
}
House dust mites are a significant source of airborne allergen worldwide, but there is little understanding of how they so potently generate allergic inflammation. We found that extracts from the house dust mites Dermatophagoides farinae (Df) and Dermatophagoides pteronyssinus and from the mold Aspergillus fumigatus stimulated a rapid and robust production of cysteinyl leukotrienes (cys-LTs), proinflammatory lipid mediators, from mouse bone marrow-derived dendritic cells (BMDCs). Con A affinity… CONTINUE READING

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