Dectin-1 expression and function are enhanced on alternatively activated and GM-CSF-treated macrophages and are negatively regulated by IL-10, dexamethasone, and lipopolysaccharide.

@article{Willment2003Dectin1EA,
  title={Dectin-1 expression and function are enhanced on alternatively activated and GM-CSF-treated macrophages and are negatively regulated by IL-10, dexamethasone, and lipopolysaccharide.},
  author={Janet A Willment and H Lin and Delyth M. Reid and Philip R. Taylor and David M. L. Williams and Simon Y. C. Wong and Siamon Gordon and Gordon D Brown},
  journal={Journal of immunology},
  year={2003},
  volume={171 9},
  pages={4569-73}
}
Dectin-1 is the major macrophage receptor for beta-glucans and generates a proinflammatory response through the recognition of these carbohydrates on fungal pathogens. We have examined the effects of cytokines and other agents on the expression and functions of dectin-1 in both resident and elicited murine peritoneal macrophages (Mphi). Dectin-1 expression was found to be highly up-regulated by GM-CSF and by the cytokines that induce alternative macrophage activation, IL-4 and IL-13. In… CONTINUE READING
94 Citations
32 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 94 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 32 references

Similar Papers

Loading similar papers…