Decremental effect of non-host humoral milieu interfacing viral envelope on the RNA level and surface antigenicity of hepatitis C virus (HCV) in vitro

@article{Lee2019DecrementalEO,
  title={Decremental effect of non-host humoral milieu interfacing viral envelope on the RNA level and surface antigenicity of hepatitis C virus (HCV) in vitro},
  author={Hong Jai Lee and Bo Young Shin and Jae-Seung Moon and Chun-Chang Ho and Jin-Su Shin and Soo-Ki Kim and Sheila Wei Ting. Lee},
  journal={Molecular & Cellular Toxicology},
  year={2019},
  volume={15},
  pages={239-244}
}
Backgrounds: Hepatitis C virus (HCV) has infected an estimated 170 million people worldwide, most of whom are chronic patient of HCV. However, the lack of standard in vitro culture system and suitable animal model for this virus hampers fundamental conquest against HCV infection.Methods: We evaluated whether humoral milieu such as serum or culture media, and its constituents, lipid and electrolyte and pH might affect the RNA level and envelope status of HCV in vitro, fnally increasing the… CONTINUE READING

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