Decreasing sensitivity to neuroleptic agents in developing rats; evidence for a pharmacodynamic factor

@article{Campbell1988DecreasingST,
  title={Decreasing sensitivity to neuroleptic agents in developing rats; evidence for a pharmacodynamic factor},
  author={Alexander Scott Campbell and Ross J. Baldessarini and Martin H. Teicher},
  journal={Psychopharmacology},
  year={1988},
  volume={94},
  pages={46-51}
}
Developing rats are far more sensitive than adults to the behavioral effects of haloperidol. The present results support the hypothesis that this change may reflect age-related changes in brain responses such as alterations in drug-receptor or drug-effector mechanisms. Dose-response studies of catalepsy and ptosis were conducted in male Sprague-Dawley rats aged 30, 56, or 100 days. Resulting dose-effect curves were approximately parallel and showed rightward shifts with highly significant… CONTINUE READING
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