Decreasing intracellular superoxide corrects defective ischemia-induced new vessel formation in diabetic mice.

@article{Ceradini2008DecreasingIS,
  title={Decreasing intracellular superoxide corrects defective ischemia-induced new vessel formation in diabetic mice.},
  author={Daniel J Ceradini and Dachun Yao and Raymon H. Grogan and Matthew J Callaghan and Diane Edelstein and Michael Brownlee and Geoffrey C. Gurtner},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 16},
  pages={10930-8}
}
Tissue ischemia promotes vasculogenesis through chemokine-induced recruitment of bone marrow-derived endothelial progenitor cells (EPCs). Diabetes significantly impairs this process. Because hyperglycemia increases reactive oxygen species in a number of cell types, and because many of the defects responsible for impaired vasculogenesis involve HIF1-regulated genes, we hypothesized that HIF1 function is impaired in diabetes because of reactive oxygen species-induced modification of HIF1alpha by… CONTINUE READING

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Superoxide and Impaired Vasculogenesis 10938 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

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