Decreasing initial telomere length in humans intergenerationally understates age-associated telomere shortening

@inproceedings{Holohan2015DecreasingIT,
  title={Decreasing initial telomere length in humans intergenerationally understates age-associated telomere shortening},
  author={Brody Holohan and Tim de Meyer and Kimberly G. Batten and Massimo Mangino and Steven C. Hunt and Sofie Bekaert and Marc L D De Buyzere and Ernst R. Rietzschel and Tim D. Spector and Woodring E Wright and Jerry W Shay},
  booktitle={Aging cell},
  year={2015}
}
Telomere length shortens with aging, and short telomeres have been linked to a wide variety of pathologies. Previous studies suggested a discrepancy in age-associated telomere shortening rate estimated by cross-sectional studies versus the rate measured in longitudinal studies, indicating a potential bias in cross-sectional estimates. Intergenerational changes in initial telomere length, such as that predicted by the previously described effect of a father's age at birth of his offspring (FAB… CONTINUE READING