Decreasing effective nanofluidic filter size by modulating electrical double layers: separation enhancement in microfabricated nanofluidic filters.

@article{Bow2008DecreasingEN,
  title={Decreasing effective nanofluidic filter size by modulating electrical double layers: separation enhancement in microfabricated nanofluidic filters.},
  author={Hansen Bow and Jianping Fu and Jongyoon Han},
  journal={Electrophoresis},
  year={2008},
  volume={29 23},
  pages={
          4646-51
        }
}
Conventional methods for separating biomolecules are based on steric interactions between the biomolecules and randomly oriented gel fibers. The recently developed artificial molecular sieves also rely on steric interactions for separation. In this work, we present an experimental investigation of a method that can be used in these sieves to increase separation selectivity and resolution. This method exploits the electrostatic repulsion between the charged molecules and the charged nanofluidic… CONTINUE READING

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