Decreases in percentages of naïve CD4 and CD8 T cells and increases in percentages of memory CD8 T-cell subsets in the peripheral blood lymphocyte populations of A-bomb survivors.

@article{Yamaoka2004DecreasesIP,
  title={Decreases in percentages of na{\"i}ve CD4 and CD8 T cells and increases in percentages of memory CD8 T-cell subsets in the peripheral blood lymphocyte populations of A-bomb survivors.},
  author={Mika Yamaoka and Yoichiro Kusunoki and Fumiyoshi Kasagi and Tomonori Hayashi and Kei Nakachi and Seishi Kyoizumi},
  journal={Radiation research},
  year={2004},
  volume={161 3},
  pages={290-8}
}
Our previous studies have revealed a clear dose-dependent decrease in the percentage of naïve CD4 T cells that are phenotypically CD45RA+ in PBL among A-bomb survivors. However, whether there is a similar radiation effect on CD8 T cells has remained undetermined because of the unreliability of CD45 isoforms as markers of naïve and memory subsets among the CD8 T-cell population. In the present study, we used double labeling with CD45RO and CD62L for reliable identification of naïve and memory… CONTINUE READING

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