Decreases Immune Suppression in the Tumor OX40 Agonist Therapy Enhances CD8 Infiltration and Updated Version

Abstract

Acquisition of full T-cell effector function and memory differentiation requires appropriate costimulatory signals, including ligation of the costimulatory molecule OX40 (TNFRSF4, CD134). Tumors often grow despite the presence of tumor-specific T cells and establish an environment with weak costimulation and immune suppression. Administration of OX40… (More)

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6 Figures and Tables