Decreases Immune Suppression in the Tumor OX40 Agonist Therapy Enhances CD8 Infiltration and Updated Version


Acquisition of full T-cell effector function and memory differentiation requires appropriate costimulatory signals, including ligation of the costimulatory molecule OX40 (TNFRSF4, CD134). Tumors often grow despite the presence of tumor-specific T cells and establish an environment with weak costimulation and immune suppression. Administration of OX40… (More)


6 Figures and Tables