Decreased zinc and downregulation of ZIP3 zinc uptake transporter in the development of pancreatic adenocarcinoma.

@article{Costello2011DecreasedZA,
  title={Decreased zinc and downregulation of ZIP3 zinc uptake transporter in the development of pancreatic adenocarcinoma.},
  author={Leslie C. Costello and Bernard A Levy and Mohamed Mokhtar Desouki and Jing Zou and Omar Bagasra and Leslie A. Johnson and Nader Hanna and Renty B. Franklin},
  journal={Cancer biology & therapy},
  year={2011},
  volume={12 4},
  pages={297-303}
}
Pancreatic adenocarcinoma is an untreatable deadly cancer. The factors involved in its early development remain unknown; which contributes to the absence of biomarkers for early detection of malignancy or at-risk subjects, and the absence of efficacious therapeutic agents. Because zinc changes are implicated in some cancers, we determined if it might be involved in the development of pancreatic adenocarcinoma. With in situ Dithizone and Zinquin staining of normal pancreas and adenocarcinoma… CONTINUE READING

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