Decreased whole body endogenous nitric oxide production in patients with primary pulmonary hypertension.

@article{Demoncheaux2005DecreasedWB,
  title={Decreased whole body endogenous nitric oxide production in patients with primary pulmonary hypertension.},
  author={Eric A. G. Demoncheaux and Tim W Higenbottam and David G Kiely and J Wong and Simon M Wharton and Richard W Varcoe and Tom Siddons and Alan C Spivey and Keith Hall and Andy P Gize},
  journal={Journal of vascular research},
  year={2005},
  volume={42 2},
  pages={133-6}
}
Impaired pulmonary release of nitric oxide (NO) is one of the characteristic phenotypic changes of vascular cells in pulmonary hypertension. The aim of this study was to determine nitric oxide synthase (NOS)-dependent whole body NO production in patients with primary pulmonary hypertension. NOS-dependent whole body NO production was assessed by giving an intravenous infusion of L-[(15)N](2)-arginine (50 micromol/min for 30 min) and measuring isotopic urinary enrichment of (15)N-nitrite and (15… CONTINUE READING
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