Decreased vasodilator response to isoproterenol during nitric oxide inhibition in humans.

@article{Cardillo1997DecreasedVR,
  title={Decreased vasodilator response to isoproterenol during nitric oxide inhibition in humans.},
  author={Carmine Cardillo and Crescence M Kilcoyne and Arshed A Quyyumi and Richard O. Cannon and Julio A. Panza},
  journal={Hypertension},
  year={1997},
  volume={30 4},
  pages={918-21}
}
The vasodilator effect of beta-adrenergic agonists has traditionally been ascribed solely to a direct effect on vascular smooth muscle. Experimental studies, however, have suggested a role of endothelium-derived nitric oxide (NO) in beta-adrenergic-mediated vasodilation. The purpose of this investigation was to determine whether NO contributes to the vasodilator effect of beta-adrenergic stimulation in humans. We analyzed the forearm blood flow response to increasing doses of isoproterenol (50… CONTINUE READING