Decreased utilization of [2-3H]glycerol in phospholipid and neutral glyceride biosynthesis in the retina of streptozotocin-diabetic rats.

The effect of streptozotocin (STZ)-induced diabetes on lipid uptake was studied in the rat retina. The intravitreal incorporation of [2-3H]glycerol was followed in retinal lipids from the first day of diabetes (acute state) up to 20 wk (chronic state). Total lipid incorporation decreased 50% 2 d after injection of STZ; the labeling remained lower than the… CONTINUE READING