Decreased tyrosine transport in fibroblasts from schizophrenic patients.

  title={Decreased tyrosine transport in fibroblasts from schizophrenic patients.},
  author={Lars Hagenfeldt and Nikolaos Venizelos and Lars Bjerkenstedt and F A Wiesel},
  journal={Life sciences},
  volume={41 25},
Amino acid transport was studied in vitro in cultured fibroblasts from schizophrenic patients and controls. An isolated decrease in the transport capacity (Vmax) for tyrosine was observed in cells from the patients. The Km for tyrosine transport was unaffected. The kinetic parameters for phenylalanine, tryptophan, leucine and glycine transport did not differ between patients and controls. Competitive inhibition among the amino acids transported by the L-system and its exchange properties were… CONTINUE READING

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