Decreased transferrin and increased transferrin saturation in sera of women with preeclampsia: implications for oxidative stress.

@article{Hubel1996DecreasedTA,
  title={Decreased transferrin and increased transferrin saturation in sera of women with preeclampsia: implications for oxidative stress.},
  author={Carl A. Hubel and Andrey V. Kozlov and Valerian E Kagan and Robert Evans and Sandra T Davidge and Margaret K McLaughlin and James M Roberts},
  journal={American journal of obstetrics and gynecology},
  year={1996},
  volume={175 3 Pt 1},
  pages={692-700}
}
OBJECTIVE The concerted iron-binding antioxidant activity of transferrin and ceruloplasmin decreases with increasing transferrin saturation by iron. We examined interactions between serum iron and iron-binding capacity and concentrations of the lipid peroxidation metabolite malondialdehyde in normal and preeclamptic pregnancies. We also asked if the release of iron from free hemoglobin by lipid hydroperoxides is a potential mechanism to increase transferrin saturation in preeclampsia. STUDY… CONTINUE READING