Decreased thermal stability of collagens containing analogs of proline or lysine.

@article{Jimenez1974DecreasedTS,
  title={Decreased thermal stability of collagens containing analogs of proline or lysine.},
  author={Sergio A Jimenez and Joel Rosenbloom},
  journal={Archives of biochemistry and biophysics},
  year={1974},
  volume={163 2},
  pages={
          459-65
        }
}
Abstract Fibroblasts were incubated with analogs of proline or lysine and the thermal stability of procollagen molecules containing the analogs was investigated using pepsin digestion at different temperatures as an enzymatic probe of conformation. The procollagens containing either 4- cis -hydroxy- l -proline, 3,4-dehydroproline, or 4,5- trans -dehydrolysine were less stable than normal procollagen and these abnormal collagens were largely in a non-triplehelical conformation within the cells… CONTINUE READING

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