Decreased synthesis and vasodilation to nitric oxide in piglets with hypoxia-induced pulmonary hypertension.

@article{Berkenbosch2000DecreasedSA,
  title={Decreased synthesis and vasodilation to nitric oxide in piglets with hypoxia-induced pulmonary hypertension.},
  author={John W Berkenbosch and Johanne Baribeau and Therese M Perreault},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2000},
  volume={278 2},
  pages={L276-83}
}
Nitric oxide (NO) is thought to play an important role in the regulation of neonatal pulmonary vasculature. It has been suggested that neonates with pulmonary hypertension have a defective NO pathway. Therefore, we measured in 1-day-old piglets exposed to hypoxia (fraction of inspired O(2) = 0.10) for 3 or 14 days to induce pulmonary hypertension 1) the activity of NO synthase (NOS) via conversion of L-arginine to L-citrulline and the concentration of the NO precursor L-arginine in isolated… CONTINUE READING
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Altered regulation of soluble guanylate cyclase in a fetal lamb model of persistent pulmonary hypertension (Abstract)

  • R. H. Steinhorn, C. Tzao, +4 authors J. A. Russell
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