Decreased synaptic activity shifts the calcium dependence of release at the mammalian neuromuscular junction in vivo.

@article{Wang2004DecreasedSA,
  title={Decreased synaptic activity shifts the calcium dependence of release at the mammalian neuromuscular junction in vivo.},
  author={Xueyong Wang and Kathrin L. Engisch and Yingjie Li and Martin J. Pinter and Timothy C Cope and Mark M Rich},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2004},
  volume={24 47},
  pages={10687-92}
}
We examined the mechanism underlying increased quantal content after block of activity at the mouse neuromuscular junction in vivo. We found that, when quantal content was measured in solution containing normal extracellular calcium, block of activity had no effect on either quantal content or the response to repetitive stimulation. However, when quantal content was measured in low extracellular calcium, there was a large increase in quantal content after block of activity. The increase in… CONTINUE READING

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