Decreased survival and hepato-renal pathology in mice with C-terminally truncated GP73 (GOLPH2).

@article{Wright2009DecreasedSA,
  title={Decreased survival and hepato-renal pathology in mice with C-terminally truncated GP73 (GOLPH2).},
  author={Lorinda Marie Wright and Sheri Yong and Maria Mrozowicz Picken and Don C. Rockey and Claus J{\"u}ergen Fimmel},
  journal={International journal of clinical and experimental pathology},
  year={2009},
  volume={2 1},
  pages={34-47}
}
GP73 (Golph2) is a type II Golgi-localized integral membrane protein that is normally expressed in epithelial cells of many human tissues, and that is highly upregulated in liver disease. While its function is unknown, the GP73 C-terminus contains putative protein-interaction domains. We used a gene trap approach to generate mice with a severe truncation of the GP73 C-terminus (GP73(tr/tr)) in order to investigate the physiological role of this protein. GP73(tr/tr) mice were born at the… CONTINUE READING

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