Decreased substance P levels in rectal biopsies from patients with slow transit constipation.

@article{Tzavella1996DecreasedSP,
  title={Decreased substance P levels in rectal biopsies from patients with slow transit constipation.},
  author={K Tzavella and Rudolf L. Riepl and Andreas Klauser and Winfried A. Voderholzer and Norbert E. Schindlbeck and Stefan A. M{\"u}ller-Lissner},
  journal={European journal of gastroenterology & hepatology},
  year={1996},
  volume={8 12},
  pages={1207-11}
}
OBJECTIVE Previous studies in patients with chronic constipation found abnormalities in the nervous tissue of the large intestine, predominantly in the muscularis externa. Since there is evidence that the nervous system of mucosa and submucosa is also involved in the control of colonic motility we investigated the contents of vasoactive intestinal polypeptide (VIP), somatostatin and substance P in rectal biopsies of patients with slow colonic transit constipation. DESIGN AND METHODS Twenty… CONTINUE READING