Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects

  title={Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects},
  author={Nora D. Volkow and G.-J. Wang and Joanna S. Fowler and Jean Logan and Samuel John Gatley and Robert Hitzemann and Amy D Chen and Stephen L. Dewey and Naomi S Pappas},
Cocaine blocks the reuptake of dopamine, a neurotransmitter involved in the control of movement, cognition, motivation and reward. This leads to an increase in extracellular dopamine; the reinforcing effect of cocaine is associated with elevated dopamine levels in the nucleus accumbens1,2. But addiction to cocaine involves other effects, such as craving, loss of control and compulsive drug intake; the role of the dopamine system in these effects is less well-understood. We therefore used… CONTINUE READING
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