Decreased striatal D2 dopamine receptors in obese Zucker rats: changes during aging.

@article{Hamdi1992DecreasedSD,
  title={Decreased striatal D2 dopamine receptors in obese Zucker rats: changes during aging.},
  author={Amal Hamdi and Jared Porter and Chandan Prasad},
  journal={Brain research},
  year={1992},
  volume={589 2},
  pages={338-40}
}
The specific binding of [3H]YM-09151-2 was used to investigate the possible differences in age-associated changes in striatal D2 dopamine (DA) receptor properties in genetically obese (fa/fa) Zucker rats and their lean (Fa/?) littermates. The maximal binding sites (Bmax) of D2 DA receptors was found to decline with age in both obese and lean rats; the rate of decline in receptor Bmax was slightly higher in lean than obese rats. However, the Bmax of D2 DA receptor in 6-, 12- and 18-month-old… CONTINUE READING

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