Decreased spontaneous and lipopolysaccharide stimulated production of interleukin 8 by polymorphonuclear neutrophils of patients with active systemic lupus erythematosus.

@article{Hsieh1994DecreasedSA,
  title={Decreased spontaneous and lipopolysaccharide stimulated production of interleukin 8 by polymorphonuclear neutrophils of patients with active systemic lupus erythematosus.},
  author={Shu Ching Hsieh and Chia Yi Tsai and Kyung Hoon Sun and Hee Sun Yu and Sing Tsu Tsai and John Chaw Chian Wang and Y Y Tsai and Seung Hyun Han and Catherine L. Yu},
  journal={Clinical and experimental rheumatology},
  year={1994},
  volume={12 6},
  pages={
          627-33
        }
}
OBJECTIVE Interleukin 8 (IL-8) acts as a potent chemotactic cytokine and also as an autocrine factor for polymorphonuclear neutrophils (PMN), thus amplifying the acute inflammatory reaction. We undertook to study the IL-8 producing capacity of PMN in patients with systemic lupus erythematosus (SLE). METHODS PMN from twelve patients with active SLE, from fifteen patients with inactive disease and from sixteen healthy individuals were incubated for 24 hours in medium alone, or in medium with… CONTINUE READING

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