Decreased spinal morphine/clonidine antinociceptive synergism in morphine-tolerant mice.

Abstract

The antinociceptive interactions between spinally administered opioids and the alpha 2 agonist clonidine were examined in placebo and morphine pellet-implanted mice using the tail flick test. In placebo pellet-implanted animals, coadministered morphine and clonidine produced a synergistic antinociceptive effect. In mice implanted with morphine pellets, the… (More)

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