Decreased serum testosterone levels in rats exposed intraperitoneally to bismuth subnitrate.

@article{Stoltenberg2002DecreasedST,
  title={Decreased serum testosterone levels in rats exposed intraperitoneally to bismuth subnitrate.},
  author={Meredin Stoltenberg and Allan Flyvbjerg and Liselotte G. S\ondergaard and J Rungby},
  journal={Journal of applied toxicology : JAT},
  year={2002},
  volume={22 2},
  pages={111-5}
}
The consumption of bismuth is increasing and knowledge of the potential teratogenic and reproductive damage of bismuth exposure is fragmentary. In the present study we used autometallography (AMG)--the histochemical silver amplification technique--to trace bismuth in the testis and pituitary glands of Wistar rats injected intraperitoneally with bismuth subnitrate. Large amounts of bismuth AMG grains were concentrated in the lysosomes of Leydig cells, and serum testosterone levels were reduced… CONTINUE READING