Decreased serum brain-derived neurotrophic factor (BDNF) is associated with post-stroke depression but not with BDNF gene Val66Met polymorphism

@inproceedings{Zhou2011DecreasedSB,
  title={Decreased serum brain-derived neurotrophic factor (BDNF) is associated with post-stroke depression but not with BDNF gene Val66Met polymorphism},
  author={Z. Zhou and T. Lu and Gelin Xu and Xuan-ye Yue and Wusheng Zhu and Min-min Ma and Wen-hua Liu and Shuang-gen Zhu and Xinfeng Liu},
  booktitle={Clinical chemistry and laboratory medicine},
  year={2011}
}
Abstract Background: Decreased brain-derived neurotrophic factor (BDNF) has been demonstrated in animal models and patients with depression. [...] Key Method Results: A total of 93 patients admitted as a result of first time acute ischemic stroke were included. During the 6-month follow-up, 35 patients (37.6%) were diagnosed with PSD. Serum BDNF concentrations were decreased in PSD patients at 3–6 months after stroke (p<0.05). The serum BDNF concentrations were not associated with BDNF gene Val66Met…Expand
Serum Brain-derived neurotrophic factor levels in post-stroke depression.
TLDR
A strong relationship between serum BDNF levels at admission and the development of PSD within 3 months is demonstrated, which may open the way to the proposal of new therapeutic options. Expand
Brain-Derived Neurotrophic Factor Serum Levels and Genotype: Association with Depression during Interferon-α Treatment
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Serum BDNF Levels in Acute Stroke: A Systematic Review and Meta-Analysis
TLDR
It is concluded that in the acute stroke phase, stroke severity is negatively correlated with BDNF levels, and patients with acute stroke have significantly lowerBDNF levels in serum compared to healthy controls. Expand
Decreased Serum Brain-Derived Neurotrophic Factor May Indicate the Development of Poststroke Depression in Patients with Acute Ischemic Stroke: A Meta-Analysis.
  • H. Xu, Yuhong Xu, +4 authors J. Wu
  • Medicine
  • Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
  • 2018
TLDR
This study suggests a potential association between circulating BDNF concentrations at admission and subsequent PSD development, and provides additional support for the involvement of BDNF in thePSD development. Expand
Lack of an association of BDNF Val66Met polymorphism and plasma BDNF with hippocampal volume and memory
TLDR
Findings suggest that BDNF genotype and plasma BDNF may not be robust predictors for variance in hippocampal volume and memory in middle age and older adult cohorts. Expand
The role of brain-derived neurotrophic factor and its single nucleotide polymorphisms in stroke patients.
TLDR
There is a consistent trend of Met alleles' being connected with worse outcomes and prognoses after stroke, however, there is no satisfactory data confirming the importance of Met allele in stroke epidemiology and the post-stroke rehabilitation process. Expand
Increase in Serum Brain-Derived Neurotrophic Factor in Met Allele Carriers of the BDNF Val66Met Polymorphism Is Specific to Males
TLDR
The findings of this study may partly explain the inconsistent findings of earlier studies where results were influenced by male-female ratios. Expand
The Relationship between Serum Brain Derived Neurotrophic Factor Levels and Post Stroke Depression in Chinese Patients : A Meta-Analysis
Background: To explore the relationship between serum brain derived neurotrophic factor (BDNF) level and post stroke depression (PSD). Methods: Prospective randomized controlled trails of theExpand
Brain-Derived Neurotrophic Factor as a Clinical Biomarker in Predicting the Development of Post-Stroke Depression: A Review of Evidence
TLDR
A review of evidence with respect to changes in the expression of BDNF in patients with PSD reveals associations between changes in serum BDNF levels and depression following stroke. Expand
Brain‐derived neurotrophic factor and post‐stroke depression
TLDR
This review summarizes the current knowledge of BDNF in PSD and suggests a synergistic effect may be achieved when such treatments are applied together with existing antidepressants. Expand
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