Decreased serum arylesterase activity in autism spectrum disorders.

  title={Decreased serum arylesterase activity in autism spectrum disorders.},
  author={Laura Gaita and Barbara Manzi and Roberto Sacco and C Lintas and Laura Altieri and Federica Lombardi and Tracy L Pawlowski and Margot Redman and David W. Craig and Matthew J. Huentelman and Sharman Ober-Reynolds and Sarah Brautigam and Raun D Melmed and Christopher J Smith and Judith Marsillach and Jordi Camps and Paolo Curatolo and Antonio M Persico},
  journal={Psychiatry research},
  volume={180 2-3},
The PON1 gene, previously found associated with autism spectrum disorders (ASDs), encodes a serum protein responsible for the detoxification of organophosphates (OPs) and able to exert several enzymatic activities. PON1 arylesterase, but not diazoxonase activity, was significantly decreased in 174 ASD patients compared to 175 first-degree relatives and 144 controls (P=2.65×10⁻¹⁶). First degree relatives displayed intermediate activities, closer to patient than to control levels. Differences… CONTINUE READING
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